Retatrutide is a 39-residue, lipid-modified research peptide engineered for activity at three class B G protein-coupled receptors: the GLP-1 receptor, the glucose-dependent insulinotropic polypeptide (GIP) receptor, and the glucagon receptor. This triple-receptor profile has made retatrutide a widely studied tool for investigating multi-receptor incretin signaling and the interactions between these pathways in metabolic research.

Structural and translational studies have examined how retatrutide engages conserved receptor-binding regions while producing receptor-specific conformational responses. Research programs have evaluated endpoints including glucose regulation, lipid handling, energy balance, hepatic fat markers, pancreatic islet function, and body-weight trajectories in preclinical and clinical study settings.

Retatrutide is therefore commonly described in the research literature as a GLP-1/GIP/glucagon triple agonist and is used as a reference compound for studying the pharmacology of coordinated multi-receptor activation. Prime Biology supplies this material strictly for laboratory and research use.

Research use only. This product is intended exclusively for laboratory and research applications and is not for human or veterinary use.